{"product_id":"cst-43339t","title":"CST,  43339T, FLASH\/CASP8AP2 (D3T8Q) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CASP8AP2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, FLASH\/CASP8AP2 (D3T8Q) Rabbit Monoclonal Antibody (CST #43339) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nFLASH\/CASP8AP2 (D3T8Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total FLASH\/CASP8AP2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to residues near the amino terminus of human FLASH\/CASP8AP2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nFLICE associated huge protein (FLASH), also termed Caspase 8 associated protein 2 (CASP8AP2), is a large multifunctional protein that has been shown to be involved in multiple processes, including apoptosis, cell cycle progression, and transcriptional regulation (1-3). It was originally identified as a component of the FAS-FADD-Caspase 8 complex with a role in the activation of caspase-8 during Fas-mediated apoptosis (1). However, studies suggest additional functions for FLASH\/CASP8AP2 in the nucleus within Cajal and PML bodies (3-5). One of the functions identified was its ability to regulate histone gene processing and S-phase progression (3,6). FLASH\/CASP8AP2 has also been found to regulate the activity of transcription factors, including the glucocorticoid receptor and c-Myb (2,7). Furthermore, FLASH\/CASP8AP2 was found to stabilize the expression of ZEB1, a transcriptional repressor of genes associated with epithelial-to-mesenchymal transition (EMT), a process associated with cancer metastasis (8). Aberrant expression as well as genetic mutations in the gene have been described in several cancers and it has been suggested to be a prognostic indicator in acute lymphoblastic leukemia (9-14).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC8AP2; CASP8 associated protein 2; CASP8-associated protein 2; CASP8AP2; caspase 8 associated protein 2; CED-4; FLASH; FLASH homolog RIP25; FLICE associated huge; FLICE-associated huge protein; FLJ11208; human FLASH; KIAA1315; RIP25\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 223\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799504310441,"sku":"43339T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-43339t","provider":"Iright","version":"1.0","type":"link"}