{"product_id":"cst-43514t","title":"CST,  43514T, CD141\/Thrombomodulin (E7Y9P) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CD141. Validated for WB,IP,IHC,IHC. Available in 2 sizes. Highly specific and rigorously validated in-house, CD141\/Thrombomodulin (E7Y9P) Rabbit Monoclonal Antibody (CST #43514) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\nIHC Leica Bond: 1:100 - 1:400\nImmunohistochemistry (Paraffin): 1:200 - 1:800\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 34149 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, IHC Leica Bond, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD141\/Thrombomodulin (E7Y9P) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD141\/Thrombomodulin protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with human CD141\/Thrombomodulin recombinant protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCD141\/Thrombomodulin (TM, THBD, BDCA-3) is an integral membrane protein expressed on the surface of endothelial cells (1). Acting as a cofactor with Thrombin, CD141\/Thrombomodulin activates and initiates the Protein C anticoagulant pathway (1,2). CD141\/Thrombomodulin is expressed by a small subset of human CD11c+ myeloid dendritic cells (3-4). These CD141+XCR1+ dendritic cells cross-present antigens to naïve CD8+ T cells, priming them to become activated cytotoxic CD8+ T cells (3-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAHUS6; BDCA3; CD141; CD141 antigen; Fetomodulin; THBD; THPH12; THRM; Thrombomodulin; TM; TRBM\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 90\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799505457321,"sku":"43514T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-43514t","provider":"Iright","version":"1.0","type":"link"}