{"product_id":"cst-43584s","title":"CST,  43584S, APOBEC3G (D9C6Z) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying APOBEC3G. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, APOBEC3G (D9C6Z) Rabbit Monoclonal Antibody (CST #43584) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAPOBEC3G (D9C6Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total APOBEC3G protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly255 of human APOBEC3G protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nAPOBEC3G, a single-strand DNA deaminase that converts deoxycytidine to deoxyuridine (1-3), is a cellular restriction factor blocking the replication of retroviruses (3). It suppresses the replication of human immunodeficiency virus-1 (HIV-1) in T-cells by being packaged into progeny virions and deaminating cytosine to uracil in the nascent minus-strand viral DNA, leading to the accumulation of mutations in the viral genome (1-4). The HIV-1 virion infectivity factor (Vif) inhibits APOBEC3G activity by preventing its incorporation into progeny virions (4,5). In addition, Vif targets APOBEC3G for ubiquitination and subsequent degradation (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nA3G; ABC3G; APOBEC-related cytidine deaminase; APOBEC-related protein; APOBEC-related protein 9; APOBEC3G; apolipoprotein B editing enzyme catalytic polypeptide-like 3G; apolipoprotein B mRNA editing enzyme catalytic subunit 3G; apolipoprotein B mRNA editing enzyme cytidine deaminase; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15; CEM15; Deoxycytidine deaminase; dJ494G10.1; DNA dC-\u0026gt;dU editing enzyme; DNA dC-\u0026gt;dU-editing enzyme APOBEC-3G; FLJ12740; MDS019; phorbolin-like protein MDS019\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 40\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799506276521,"sku":"43584S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-43584s","provider":"Iright","version":"1.0","type":"link"}