{"product_id":"cst-43603s","title":"CST,  43603S, Cyclophilin B (D1V5J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PPIB. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, Cyclophilin B (D1V5J) Rabbit Monoclonal Antibody (CST #43603) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCyclophilin B (D1V5J) Rabbit Monoclonal Antibody recognizes endogenous levels of total cyclophilin B protein. This antibody does not cross-react with cyclophilin A protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human cyclophilin B protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCyclophilin B (CyPB) is an ER-localized chaperone protein belonging to the family of peptidyl-prolyl cis-trans isomerases (PPIases) (1,2). Research studies have demonstrated that CyPB associates with type I procollagen and is involved in its sorting and transport through the secretory compartment (3). Mutations in the gene encoding CyPB, , lead to aberrant biosynthesis of type I procollagen, which underlies the pathogenesis of osteogenesis imperfecta (OI), a disorder characterized by bone fragility (4-7). In additional to its role in OI, research studies demonstrate that CyPB overexpression supports the expression of multiple oncogenic drivers of glioblastoma multiforme (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB; Cyclophilin B; cyclophilin-like protein; CYP-S1; CYPB; epididymis secretory protein Li 39; HEL-S-39; MGC14109; MGC2224; OI9; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase B; PPIB; Rotamase B; S-cyclophilin; SCYLP\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 20\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799506473129,"sku":"43603S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-43603s","provider":"Iright","version":"1.0","type":"link"}