{"product_id":"cst-43924s","title":"CST,  43924S, MX2 (E7Y8H) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MX2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MX2 (E7Y8H) Rabbit Monoclonal Antibody (CST #43924) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMX2 (E7Y8H) Rabbit Monoclonal Antibody recognizes endogenous levels of total MX2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn175 of human MX2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMx2 (MxB) is a dynamin-like GTPase that is highly upregulated by IFN-α and IFN-β and upregulated to a lesser extent by IFN-γ (1). It was identified as a potent cell-autonomous HIV restriction factor (2). Mx2 functions as an HIV restriction factor by blocking infection at the late post-entry step through prevention of nuclear accumulation and chromosomal integration (2). HIV restriction by Mx2 is dictated through the capsid region of the viral Gag protein (2).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nInterferon-induced GTP-binding protein Mx2; Interferon-regulated resistance GTP-binding protein MxB; MX dynamin like GTPase 2; MX2; MXB; myxovirus (influenza virus) resistance 2; myxovirus (influenza virus) resistance 2 (mouse); Myxovirus resistance protein 2; p78-related protein; second interferon-induced protein p78\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 80\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799508930729,"sku":"43924S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-43924s","provider":"Iright","version":"1.0","type":"link"}