{"product_id":"cst-4456s","title":"CST,  4456S, Nna1 Antibody","description":"Polyclonal Antibody for studying AGTPBP1. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, Nna1 Antibody (CST #4456) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNna1 Antibody detects endogenous levels of total Nna1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp1175 of human Nna1 protein. Antibodies are purified by protein A and peptide affinity chromatography\n\u003cb\u003eBackground\u003c\/b\u003e\nervous system uclear protein induced by xotomy (Nna1, AGTPBP1 or cytosolic carboxypeptidase-1) is related to zinc carboxypeptidases and contains an ATP\/GTP binding motif, a basic and a bipartite nuclear localization signal. Nna1 expression is rapidly induced in motor neurons following axotomy and down-regulated following reinnervation, which is consistent with abundant Nna1 expression in differentiating neurons and the absence of Nna1 in CNS proliferative zones (1). Furthermore, Purkinje cell degeneration is characterized by adult onset neurodegeneration resulting from Nna1 gene mutations, implicating Nna1 in mechanisms common to degeneration and regeneration (2).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAGTPBP1; ATP\/GTP binding protein 1; ATP\/GTP-binding protein 1; carboxypeptidase-tubulin; CBPC1; CCP1; CONDCA; Cytosolic carboxypeptidase 1; DKFZp686M20191; KIAA1035; Nervous system nuclear protein induced by axotomy; Nervous system nuclear protein induced by axotomy protein 1 homolog; NNA1; soluble carboxypeptidase; tubulinyl-Tyr carboxypeptidase; tyrosine carboxypeptidase\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 145\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799513288873,"sku":"4456S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-4456s","provider":"Iright","version":"1.0","type":"link"}