{"product_id":"cst-45339s","title":"CST,  45339S, Cav2.2\/CACNA1B (E2Q1Y) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Cav2.2 mouse. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Cav2.2\/CACNA1B (E2Q1Y) Rabbit Monoclonal Antibody (CST #45339) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCav2.2\/CACNA1B (E2Q1Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total Cav2.2\/CACNA1B protein.\nSpecies Reactivity: Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala1938 of mouse Cav2.2\/CACNA1B protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nVoltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells. VSCCs are involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. Calcium channel, voltage-dependent, N type, alpha 1B subunit (CACNA1B), or Cav2.2, is encoded by the gene (1,2). In the brain, Cav2.2 has been implicated in synaptic plasticity (3). Interestingly, altered Cav2.2 may contribute to some neurodegenerative diseases, such as Huntington's disease (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nalpha(1B); AW050276; AW060892; AW822256; BIII; Brain calcium channel III; CAC1B; Cach5; Cacna1b; Cacnl1a5; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide isoform 5; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, N type, alpha 1B subunit; calcium channel, voltage-dependent, N type, alpha 1B subunit, BIII; Cav2; Cav2.2; Cchn; Cchn1a; OTTMUSP00000012891; OTTMUSP00000013173; Voltage-dependent N-type calcium channel subunit alpha-1B; Voltage-gated calcium channel subunit alpha Cav2.2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M R\nSENSITIVITY: Endogenous\nMW (kDa): 190\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800097706153,"sku":"45339S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-45339s","provider":"Iright","version":"1.0","type":"link"}