{"product_id":"cst-45457s","title":"CST,  45457S, Matrin 3 (F4Q5F) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying matrin 3. Validated for WB,WB,IP,IF,IF. Available in 2 sizes. Highly specific and rigorously validated in-house, Matrin 3 (F4Q5F) Rabbit Monoclonal Antibody (CST #45457) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunoprecipitation: 1:100\nImmunofluorescence (Frozen): 1:50 - 1:100\nImmunofluorescence (Immunocytochemistry): 1:400 - 1:1600\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Frozen), Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMatrin 3 (F4Q5F) Rabbit Monoclonal Antibody recognizes endogenous levels of total matrin 3 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human matrin 3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMatrin 3 (MATR3) is a nuclear protein with two zinc finger domains, two RNA recognition motifs, and two intrinsically disordered regions. This protein is able to bind both DNA and RNA sequences and is a critical component of the nuclear matrix (1-4). MATR3 was initially implicated in human disease through its identification in a family with an autosomal dominant form of vocal cord and pharyngeal distal myopathy (5). Since then, exome sequencing has identified over a dozen point mutations in the gene that have been linked to familial amyotrophic lateral sclerosis (ALS) and combined ALS\/frontotemporal dementia (6-8). Moreover, abnormal MATR3 abundance, localization, and aggregation have been reported in motor neurons of patients with sporadic ALS (9,10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nALS21; DKFZp686K0542; DKFZp686K23100; KIAA0723; MATR3; matrin 3; Matrin-3; MGC9105; MPD2; VCPDM; vocal cord and pharyngeal weakness with distal myopathy\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 125\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799520366761,"sku":"45457S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-45457s","provider":"Iright","version":"1.0","type":"link"}