{"product_id":"cst-45774s","title":"CST,  45774S, ML-241","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nML-241 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 0.89 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 4 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles .\n\u003cb\u003eBackground\u003c\/b\u003e\nML-241 is an inhibitor of valosin-containing protein (VCP, p97), which is part of an ATPase protein complex that regulates several critical cellular processes, including the proteasomal degradation of ubiquitinated proteins and autophagosome maturation. ML-241 inhibits VCP (IC of approximately 100 nM), blocks degradation of p97-dependent proteasome substrates (IC of approximately 3,500 nM), and impairs the endoplasmic reticulum (ER)-associated degradation pathway (1). VCP forms a hexamer with a pair of ATPase domains (D1 and D2) and an N-terminal domain that binds numerous cofactor proteins. Both ML-241 and the related inhibitor ML-240 specifically bind the D2 ATPase domain, while a second pair of inhibitors (DBeQ and NMS-873) are capable of binding and inhibiting both D1 and D2 ATPase domains (2). The p47 cofactor of VCP is shown to attenuate ML-241 inhibition of VCP by a factor of approximately 50-fold (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCID49830260; N-Benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine","brand":"CST","offers":[{"title":"Default Title","offer_id":46800695099561,"sku":"45774S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-45774s","provider":"Iright","version":"1.0","type":"link"}