{"product_id":"cst-45833t","title":"CST,  45833T, SPTLC2 (F7M8B) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SPTLC2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, SPTLC2 (F7M8B) Rabbit Monoclonal Antibody (CST #45833) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSPTLC2 (F7M8B) Rabbit Monoclonal Antibody recognizes endogenous levels of total SPTLC2 protein. This antibody does not cross-react with SPTLC1 or SPTLC3 proteins.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human SPTLC2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSerine palmitoyltransferase 2 (SPTLC2) is a component of the serine palmitoyltransferase (SPT) multisubunit enzyme, the principal enzyme facilitating the initial, rate-limiting step in sphingolipid biosynthesis (1,3-5). This protein complex consists of an SPTLC1\/SPTLC2 or SPTLC1\/SPTLC3 heterodimer as the catalytic core (1-3). Sphingolipid biosynthesis generates long-chain based compounds by condensing serine with activated acyl-CoA to form ketodihydrosphingosine (3,4). mutations have been linked to hereditary sensory and autonomic neuropathy type I (HSAN1), frontotemporal dementia (FTD), and early-onset amyotrophic lateral sclerosis (ALS) (2,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nhLCB2a; HSN1C; KIAA0526; LCB 2; LCB2; LCB2a; Long chain base biosynthesis protein 2; Long chain base biosynthesis protein 2a; NSAN1C; Serine palmitoyltransferase 2; serine palmitoyltransferase long chain base subunit 2; serine palmitoyltransferase, long chain base subunit 2; serine palmitoyltransferase, subunit II; Serine-palmitoyl-CoA transferase 2; SPT 2; SPT2; SPTC2; SPTLC2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 63\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799525052585,"sku":"45833T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-45833t","provider":"Iright","version":"1.0","type":"link"}