{"product_id":"cst-45859s","title":"CST,  45859S, MT-ND3 Antibody","description":"Polyclonal Antibody for studying MT-ND3. Validated for Western Blotting. Highly specific and rigorously validated in-house, MT-ND3 Antibody (CST #45859) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMT-ND3 Antibody recognizes endogenous levels of total MT-ND3 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MT-ND3 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nMitochondrially encoded NADH dehydrogenase 3 (MT-ND3) is encoded by the mitochondrial gene and is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Located in the mitochondrial inner membrane, Complex I is the largest of the five respiratory complexes and catalyzes electron transfer from NADH to ubiquinone. The mitochondrially encoded subunits of Complex I, including MT-ND3, are the most hydrophobic subunits and form the core of the transmembrane region (1,2). Pathogenic variants of the gene are known to cause mitochondrial complex I deficiency (MT-C1D) and may lead to a wide range of clinical disorders, including Leigh syndrome, Leber hereditary optic neuropathy, and encephalopathy (3-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nmitochondrially encoded NADH dehydrogenase 3; MT-ND3; MTND3; NADH dehydrogenase subunit 3; NADH dehydrogenase, subunit 3 (complex I); NADH-ubiquinone oxidoreductase chain 3; NADH3; ND3; NU3M\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 13\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799525937321,"sku":"45859S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-45859s","provider":"Iright","version":"1.0","type":"link"}