{"product_id":"cst-45889s","title":"CST,  45889S, PRPF3 (F8X1N) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PRPF3. Validated for Western Blotting,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, PRPF3 (F8X1N) Rabbit Monoclonal Antibody (CST #45889) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunofluorescence (Immunocytochemistry): 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPRPF3 (F8X1N) Rabbit Monoclonal Antibody recognizes endogenous levels of total PRPF3 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu672 of human PRPF3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPre-mRNA processing factor 3 (PRPF3) is a U4\/U6 snRNP-associated protein that is a critical regulator of the splicing process (1-3). PRPF3, PRPF4, and PPIH form a stable complex essential for the proper formation and function of the U4\/U6.U5 tri-snRNP (3). PRPF3 interacts with SPF30, which forms a bridge between tri-snRNP and U2AF35, a protein that recognizes 3' splice sites (4). mutations cause autosomal dominant retinitis pigmentosa (5,6). Furthermore, has been identified as a potential oncogene in hepatocellular carcinoma (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nHPRP3; HPRP3P; pre-mRNA processing factor 3; Pre-mRNA-splicing factor 3; PRP3; PRP3 pre-mRNA processing factor 3 homolog; PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae); Prp3p; PRPF3; RP18; SNRNP90; U4\/U6 small nuclear ribonucleoprotein Prp3; U4\/U6 snRNP 90 kDa protein; U4\/U6-associated RNA splicing factor\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 85\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799526592681,"sku":"45889S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-45889s","provider":"Iright","version":"1.0","type":"link"}