{"product_id":"cst-4592t","title":"CST,  4592T, Bik Antibody","description":"Polyclonal Antibody for studying Bik. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Bik Antibody (CST #4592) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nBik Antibody detects endogenous levels of Bik protein. This antibody does not cross-react with other Bcl-2 family members.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with synthetic peptide corresponding to residues surrounding Asp40 of human Bik protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nBik\/Nbk (Bcl-2-interacting killer\/natural born killer) is a potent pro-apoptotic protein belonging to a group of Bcl-2 family members that includes Bad, Bid, Bim, Hrk, and Noxa, containing a BH3 domain but lacking other conserved domains, BH1 or BH2 (1,2). Functionally, Bik is able to bind to and antagonize anti-apoptotic Bcl-2 family members including Bcl-2, Bcl-xL, and viral homologs E1B-19K and EBV-BHFR1. The BH3 domain of Bik is essential for its apoptotic activity and interaction with survival proteins (3). Phosphorylation of Bik is correlated with an increase in its pro-apoptotic activity (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nApoptosis inducer NBK; apoptosis-inducing NBK; Bcl-2-interacting killer; BCL2 interacting killer; BCL2-interacting killer (apoptosis-inducing); BIK; BIP1; BP4; natural born killer; NBK\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 20\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799527837865,"sku":"4592T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-4592t","provider":"Iright","version":"1.0","type":"link"}