{"product_id":"cst-45948s","title":"CST,  45948S, TIMM17A (E6F3I) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TIMM17A. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TIMM17A (E6F3I) Rabbit Monoclonal Antibody (CST #45948) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTIMM17A (E6F3I) Rabbit Monoclonal Antibody recognizes endogenous levels of total TIMM17A protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro160 of human TIMM17A protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTIMM17A (mitochondrial import inner membrane translocase subunit Tim17-A) is a component of the TIM23 mitochondrial transport complex, the main translocase of mitochondrial matrix proteins (1). TIMM17A is a potential biomarker and therapeutic target in breast cancer, as high expression is associated with aggressiveness and poor prognosis (2-4). was identified as one of eleven genes included in a gene signature predictive of CDK4 phosphorylation, and of sensitivity to the CDK4\/6 inhibitor Palbociclib (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nInner membrane preprotein translocase Tim17a; MIMT17; Mitochondrial import inner membrane translocase subunit Tim17-A; mitochondrial inner membrane translocase; preprotein translocase; TI17A; TIM17; TIM17A; TIMM17; TIMM17A; translocase of inner mitochondrial membrane 17 homolog A; translocase of inner mitochondrial membrane 17A\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 18\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799528493225,"sku":"45948S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-45948s","provider":"Iright","version":"1.0","type":"link"}