{"product_id":"cst-46863s","title":"CST,  46863S, CD101\/IgSF2 (F6H5E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying IGSF2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CD101\/IgSF2 (F6H5E) Rabbit Monoclonal Antibody (CST #46863) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD101\/IgSF2 (F6H5E) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD101\/IgSF2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domain of human CD101\/IgSF2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCluster of differentiation molecule 101 (CD101), also known as immunoglobulin superfamily member 2 (IgSF2) and cell surface glycoprotein V7, is a type  I transmembrane glycoprotein with an extracellular region composed of seven IgV-like domains (1,2). CD101 is expressed on T cells, dendritic cells (DCs), and monocytes (3). On T cells, CD101 expression is induced following T cell receptor (TCR) stimulation and plays an immunoregulatory role, inhibiting proliferation and IL-2 production by blocking Ca2 flux and nuclear factor of activated T cells (NFAT) nuclear translocation (4). Regulatory T cells (Tregs) can express high levels of CD101 and are more suppressive than CD101 Tregs in suppression assays (5). CD101 is highly expressed on activated mucosal tissue-resident memory T cells and may play a role in balancing anti-inflammatory Tregs and pro-inflammatory Th17 cells in mucosal tissue (6). In CD8 T cells, CD101 and TIM-3 expression defines a terminally differentiated state of exhaustion and dysfunction arising from chronic viral infection (7). In cutaneous DCs, triggering CD101 may lead to IL-10 production and the suppression of T cell proliferation (8). CD101 has been identified as a prognostic marker in glioma correlating with unfavorable overall survival and was found to be expressed at high levels on M2-like tumor-associated macrophages (TAMs) (9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD101; CD101 molecule; Cell surface glycoprotein V7; EWI-101; EWI101; Glu-Trp-Ile EWI motif-containing protein 101; IGSF2; Immunoglobulin superfamily member 2; immunoglobulin superfamily, member 2; leukocyte surface protein; V7\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 130\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799535931561,"sku":"46863S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-46863s","provider":"Iright","version":"1.0","type":"link"}