{"product_id":"cst-47066s","title":"CST,  47066S, YKL-40 (E2L1M) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying YKL-40. Validated for WB,WB,IHC,IF. Available in 2 sizes. Highly specific and rigorously validated in-house, YKL-40 (E2L1M) Rabbit Monoclonal Antibody (CST #47066) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunohistochemistry (Paraffin): 1:400 - 1:1600\nImmunofluorescence (Immunocytochemistry): 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 44073 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin), Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nYKL-40 (E2L1M) Rabbit mAb recognizes endogenous levels of total YKL-40 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human YKL-40 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nYKL-40, also known as chitinase-3-like protein 1 (CHI3L1), is a secreted glycoprotein encoded by the gene (1,2). Unlike other members of the chitinase-like protein family, YKL-40 is not an active chitinase. It is produced by activated macrophages, chondrocytes, neutrophils, and synovial cells. It is a pro-inflammatory molecule that contributes to the progression of many inflammatory diseases, including fibrosis, neurodegenerative disease, breast, lung, prostate, liver, bladder, colon, and other types of cancers (3,4). Levels of YKL-40 in serum and plasma in patients with various types of tumors have been reported to predict poor prognosis, and in some clinical assays, YKL-40 is being used as a predictive biomarker of cancer outcome (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n39 kDa synovial protein; ASRT7; Cartilage glycoprotein 39; CGP-39; CH3L1; CHI3L1; chitinase 3 like 1; chitinase 3-like 1; chitinase 3-like 1 (cartilage glycoprotein-39); Chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 30-40\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799537864873,"sku":"47066S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-47066s","provider":"Iright","version":"1.0","type":"link"}