{"product_id":"cst-47500t","title":"CST,  47500T, LRRC31 (F7I7Z) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying LRRC31. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, LRRC31 (F7I7Z) Rabbit Monoclonal Antibody (CST #47500) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLRRC31 (F7I7Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total LRRC31 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LRRC31 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nLeucine-rich repeat-containing protein 31 (LRRC31) belongs to the LRR superfamily, which plays an important role in cell cycle regulation, chromosome stability, apoptosis, and DNA repair (1,2). LRRC31 functions as a tumor suppressor in cancer development. In lung adenocarcinoma (LUAD), β-hydroxybutyrate dehydrogenase 1 (BDH1) promotes LUAD progression through downregulation of LRRC31 expression (3). During breast cancer metastasis to the brain, LRRC31 functions as a DNA repair inhibitor through interaction with Ku70\/Ku80 and ATR, sensitizing tumor metastasis to radiation therapy (4). In eosinophilic esophagitis (EoE), IL-13 upregulates LRRC31 expression, promoting epithelial barrier function by downregulating kallikrein expression (5). LRRC31 has also been identified as a novel regulator of pluripotency maintenance in mouse embryonic stem cells (mESCs) by facilitating Stat3 phosphorylation in the Jak\/Stat signaling pathway (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nepididymis secretory protein Li 293; epididymis secretory sperm binding protein; FLJ23259; FLJ40019; HEL-S-293; leucine rich repeat containing 31; Leucine-rich repeat-containing protein 31; LRC31; LRRC31\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 60, 53\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799544320169,"sku":"47500T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-47500t","provider":"Iright","version":"1.0","type":"link"}