{"product_id":"cst-47598s","title":"CST,  47598S, Integrin beta2 Antibody","description":"Polyclonal Antibody for studying Integrin Beta2 mouse. Validated for Western Blotting. Highly specific and rigorously validated in-house, Integrin beta2 Antibody (CST #47598) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIntegrin beta2 Antibody recognizes endogenous levels of total mouse Integrin β2 protein. This antibody does not cross-react with human Integrin β2.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser84 of mouse Integrin β2 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nIntegrins are transmembrane glycoproteins that form heterodimers consisting of one α and one β subunit. Integrin dimers act as receptors for extracellular matrix proteins and cell-surface ligands. Integrin signaling to (inside-out) and from (outside-in) extracellular molecules regulates multiple cellular processes, such as development, wound healing, immune response, invasion, metastasis, and angiogenesis (1,2). Integrin β2 (CD18) is the β subunit of the leukocyte-specific integrin family. Leukocyte integrins include Integrin β2 (CD18)\/αL (CD11a) (LFA-1, lymphocyte function associated antigen 1), Integrin β2 (CD18)\/αM (CD11b) (Mac-1), Integrin β2 (CD18)\/αX (CD11c), and Integrin β2 (CD18)\/αD (CD11d). These integrins bind to immunoglobulin superfamily members, such as ICAM-1 and VCAM-1 on endothelial cells, to mediate firm adhesion and transendothelial migration of leukocytes (3). Integrin β2 (CD18) deficiency results in LAD (leukocyte adhesion deficiency), a disease characterized by impairment of leukocyte recruitment, resulting in an inability to fight infection (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n2E6; AI528527; Cd18; Cell surface adhesion glycoproteins LFA-1\/CR3\/p150,95 subunit beta; Complement receptor C3 subunit beta; integrin beta 2; Integrin beta-2; ITB2; Itgb2; LAD; LCAMB; Lfa1; lymphocyte function associated antigen 1; Mac-1 beta; macrophage antigen-1 beta; MF17; OTTMUSP00000021575\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nMW (kDa): 95\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46800099836073,"sku":"47598S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-47598s","provider":"Iright","version":"1.0","type":"link"}