{"product_id":"cst-47676t","title":"CST,  47676T, IFIT3 (E8G5Y) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying IFIT3. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, IFIT3 (E8G5Y) Rabbit Monoclonal Antibody (CST #47676) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIFIT3 (E8G5Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total IFIT3 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro353 of human IFIT3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nIFIT3 (Interferon-induced protein with tetratricopeptide repeats 3; Retinoic acid-induced gene G protein (RIG-G)) is part of the IFIT family of interferon-stimulating genes known for their antiviral properties (1,2). IFIT3 is widely expressed in T cells, B cells, plasmacytoid and myeloid dendritic cells, neurons, and kidney cells (3,4). In response to RNA viral infection, IFIT3 regulates IRF3 activation through interaction with TBK1 and MAVS on the mitochondrion (5). IFIT3 also interacts with IFIT1, leading to inhibitory activity against viral RNA lacking the 2′-O-methylation in the cap structure (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCIG-49; cig41; CIG49; GARG-49; IFI-60K; IFI60; IFIT-3; IFIT-4; IFIT3; IFIT4; interferon induced protein with tetratricopeptide repeats 3; Interferon-induced 60 kDa protein; Interferon-induced protein with tetratricopeptide repeats 3; Interferon-induced protein with tetratricopeptide repeats 4; IRG2; ISG-60; ISG60; P60; Retinoic acid-induced gene G protein; RIG-G\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 60-65\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799555952809,"sku":"47676T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-47676t","provider":"Iright","version":"1.0","type":"link"}