{"product_id":"cst-47945l","title":"CST,  47945L, Poly(dA:dT) Sodium Salt","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nPoly(dA:dT) Sodium Salt is supplied as a lyophilized powder. To prepare a 1 mg\/mL stock solution, reconstitute the powder in 200 μL sterile, endotoxin-free water. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nPoly(dA:dT) Sodium Salt, also known as poly(deoxyadenylic-thymidylic) acid sodium salt, is a double-stranded alternating copolymer DNA model with repetitive synthetic sequences of poly(dA-dT):poly(dT-dA). Poly(dA:dT) Sodium Salt plays a role in the innate immune response by binding to pattern recognition receptors (PRRs), which are used by host cells to detect pathogen-associated molecular patterns (PAMPs) (1). This synthetic B-DNA analog can trigger intracellular DNA sensors, such as DDX41, that leads to stimulator of interferon genes (STING) activation, and downstream activation of the transcription factors NF-κB and IRF-3 (2,3). The effect of cytosolic DNA on the innate immune response is particularly important when studying viral infections (1-3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n(dA:dT); B-DNA; DNA; dsDNA; Poly; Poly(dA-dT); Poly(dA:dT); poly(deoxyadenylic-thymidylic)","brand":"CST","offers":[{"title":"Default Title","offer_id":46800695525545,"sku":"47945L","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-47945l","provider":"Iright","version":"1.0","type":"link"}