{"product_id":"cst-47988s","title":"CST,  47988S, TNFRSF17\/BCMA Antibody","description":"Polyclonal Antibody for studying TNFRSF17. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, TNFRSF17\/BCMA Antibody (CST #47988) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTNFRSF17\/BCMA Antibody recognizes endogenous levels of total TNFRSF17\/BCMA protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human TNFRSF17\/BCMA protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nB cell maturation antigen (BCMA\/TNFRSF17\/CD269) is a transmembrane glycoprotein and member of the TNFR superfamily (1). BCMA expression is largely restricted to the B cell lineage. Pro-survival signaling through this receptor plays a pivotal role in humoral immunity by regulating B cell maturation and plasma cell differentiation upon binding its ligands, BAFF and APRIL (2-6). BCMA is expressed in a number of B cell malignancies and has garnered much attention as a novel therapeutic target for the treatment of multiple myeloma due to its selective and elevated expression on the cell surface of malignant plasma cells (7-10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB cell maturation antigen; B-cell maturation factor; B-cell maturation protein; BCM; BCMA; CD269; TNF receptor superfamily member 17; TNFRSF13A; TNFRSF17; TNR17; Tumor necrosis factor receptor superfamily member 17; tumor necrosis factor receptor superfamily, member 17\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 18, 23\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799579021481,"sku":"47988S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-47988s","provider":"Iright","version":"1.0","type":"link"}