{"product_id":"cst-48475t","title":"CST,  48475T, PILRA (E7K1H) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PILRA. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PILRA (E7K1H) Rabbit Monoclonal Antibody (CST #48475) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPILRA (E7K1H) Rabbit Monoclonal Antibody recognizes endogenous levels of total PILRA protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro245 of human PILRA protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPaired immunoglobulin-like type 2 receptor alpha (PILRA) is an inhibitory surface receptor expressed by myeloid cells and other tissues, including microglia in the central nervous system, regulating immune cells and inflammation (1). It functions by recruiting cytoplasmic phosphatases like PTPN6\/SHP-1 and PTPN11\/SHP-2, blocking downstream signal transduction via their SH2 domains (2). Furthermore, PILRA plays a role as an entry co-receptor for herpes simplex virus-1 via binding of viral glycoprotein B1 (3). More recently, mutations in the gene have been implicated in Alzheimer's disease (AD) (1,4). Recent large-scale GWAS have linked the risk of developing late-onset AD in humans harboring rare variants of microglial immunoreceptors such as TREM2, CD33, and PILRA (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCell surface receptor FDF03; FDF03; Inhibitory receptor PILR-alpha; inhibitory receptor PILRalpha; paired immunoglobin like type 2 receptor alpha; paired immunoglobin-like receptor alpha; paired immunoglobin-like type 2 receptor alpha; paired immunoglobulin-like receptor alpha; Paired immunoglobulin-like type 2 receptor alpha; PILRA\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 50\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799615623337,"sku":"48475T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-48475t","provider":"Iright","version":"1.0","type":"link"}