{"product_id":"cst-48501t","title":"CST,  48501T, CDKN3 (E7O5K) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CDKN3. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, CDKN3 (E7O5K) Rabbit Monoclonal Antibody (CST #48501) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCDKN3 (E7O5K) Rabbit Monoclonal Antibody recognizes endogenous levels of total CDKN3 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro107 of human CDKN3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCDKN3 (Cyclin-Dependent Kinase Inhibitor 3)\/KAP (Kinase-Associated Phosphatase) is a dual specificity phosphatase that regulates cell cycle progression through dephosphorylation and inhibition of cyclin-dependent kinases (1). CDKN3 promotes cancer cell proliferation and invasion (2-4), as well as resistance to cisplatin (5,6). Overexpression of CDKN3 is associated with tumor progression and poor prognosis in several human cancers (5-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCDI1; Cdk-associated protein phosphatase; CDK2-associated dual specificity phosphatase; CDK2-associated dual-specificity phosphatase; CDKN3; CIP2; cyclin dependent kinase inhibitor 3; cyclin-dependent kinase inhibitor; Cyclin-dependent kinase inhibitor 3; cyclin-dependent kinase interacting protein 2; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; FLJ25787; KAP; KAP1; Kinase-associated phosphatase; MGC70625\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 23\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799620898985,"sku":"48501T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-48501t","provider":"Iright","version":"1.0","type":"link"}