{"product_id":"cst-4852s","title":"CST,  4852S, PCTAIRE 1 Antibody","description":"Polyclonal Antibody for studying Pctaire1. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, PCTAIRE 1 Antibody (CST #4852) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPCTAIRE 1 Antibody detects endogenous levels of total PCTAIRE 1.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg98 of human PCTAIRE 1 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nThree distinct PCTAIRE isoforms (PCTAIRE 1, PCTAIRE 2 and PCTAIRE 3) have been identified in humans and belong to the CDK family of serine\/threonine protein kinases. These proteins have a core kinase domain flanked by unique amino- and carboxy-terminal domains. CDK proteins are known to regulate the cell cycle. All three PCTAIRE isoforms are abundantly expressed and catalytically active in post-mitotic brain, suggesting that they may function in processes other than cell division (1). PCTAIRE 1 is a cytoplasmic phosphoprotein whose kinase activity peaks in G2 and S phase (2). While one study indicates that noncovalent interactions with a regulatory component (such as a cyclin) are necessary for catalytic activity of PCTAIRE 1, others show that the monomeric protein is fully active (3). The Cdk5\/p25 complex phosphorylates PCTAIRE 1 at Ser95, enhancing its kinase activity (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCDK16; Cell division protein kinase 16; cyclin dependent kinase 16; Cyclin-dependent kinase 16; FLJ16665; PCTAIRE; PCTAIRE-motif protein kinase 1; PCTAIRE1; PCTGAIRE; PCTK1; Serine\/threonine-protein kinase PCTAIRE-1; testis secretory sperm-binding protein Li 224n\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 65\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799620931753,"sku":"4852S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-4852s","provider":"Iright","version":"1.0","type":"link"}