{"product_id":"cst-48633t","title":"CST,  48633T, KLC1 (D2T2R) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying KLC1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, KLC1 (D2T2R) Rabbit Monoclonal Antibody (CST #48633) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nKLC1 (D2T2R) Rabbit Monoclonal Antibody recognizes endogenous levels of total KLC1 protein. This antibody also cross-reacts with an unidentified protein of 25 kDa.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly443 of human KLC1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nKinesins are heterotetrameric motor proteins that transport cargo along microtubule tracks toward their plus ends (anterograde direction) in an ATP-dependent manner. Two heavy chains contain the motor activity, while two kinesin light chains act as adaptor proteins that may be required for binding of specific cargo and\/or regulation of heavy chain catalytic activity. The amino terminus of kinesin light chain 1 (KLC1) binds to kinesin heavy chains while the KLC1 carboxy-terminal tetratricopeptide repeat (TPR) domain binds cargo (1-3). Phosphorylation of KLC1 at Ser521 by AMPK may regulate insulin granule dynamics (4,5). Research studies identify a KLC1-ALK fusion protein in human lung adenocarcinoma, and this finding may provide insight for future therapeutics (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nkinesin 2 60\/70kDa; Kinesin light chain 1; KLC; KLC 1; KLC1; KNS2; KNS2A; medulloblastoma antigen MU-MB-2.50; MGC15245\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 65, 75\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799629090985,"sku":"48633T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-48633t","provider":"Iright","version":"1.0","type":"link"}