{"product_id":"cst-48994s","title":"CST,  48994S, KT-474","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nKT-474 is supplied as a lyophilized powder. For a 1 mM stock, reconstitute 1 mg of powder in 1.15 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles .\n\u003cb\u003eBackground\u003c\/b\u003e\nKT-474, also known as KYM-001, is a potent and selective degrader of interleukin-1 receptor-associated kinase 4 (IRAK4) (1). IRAK4 is a key protein involved in the interleukin-1 receptor (IL-1R)\/toll-like receptor (TLR) signaling pathway (1-3). The IL-1R\/TLR pathway is implicated in the pathogenesis of multiple inflammatory and autoimmune conditions, including hidradenitis suppurativa (HS), psoriasis, and atopic dermatitis (AD) (1,2). By targeting and degrading IRAK4, KT-474 effectively blocks the downstream inflammatory cascade triggered by the IL-1R\/TLR pathway, reducing inflammation (1,2). In clinical trials, KT-474 reduced disease-relevant inflammatory biomarkers in the blood and skin samples of HS and AD patients and was associated with improvements in skin lesions (2,3).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800695558313,"sku":"48994S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-48994s","provider":"Iright","version":"1.0","type":"link"}