{"product_id":"cst-49189s","title":"CST,  49189S, PD-L2 (D6L5A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PDCD1LG2 mouse. Validated for IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, PD-L2 (D6L5A) Rabbit Monoclonal Antibody (CST #49189) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nIHC Leica Bond: 1:50 - 1:200\nImmunohistochemistry (Paraffin): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 64714 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: IHC Leica Bond, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPD-L2 (D6L5A) Rabbit Monoclonal Antibody recognizes endogenous levels of total PD-L2 protein. Staining of unknown specificity in mouse ovary has been observed.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala85 of mouse PD-L2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nProgrammed cell death 1 ligand 2 (PD-L2, B7-DC, CD273) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses (1,2). PD-L2 binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L2 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by activated dendritic cells, macrophages, and T cells (1,3). Similar in structure to related B7 family members, PD-L2 protein contains extracellular IgV and IgC2 domains, a transmembrane domain, and a short, cytoplasmic region. Research studies demonstrate that PD-L2 is expressed in several tumor types, including lung cancer, renal cell carcinoma, melanoma, Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma (4-7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB7-DC; B7dc; Btdc; Butyrophilin B7-DC; butyrophilin-like protein; Cd273; F730015O22Rik; MGC124039; MGC124040; OTTMUSP00000015822; PD-; PD-1 ligand 2; PD-L2; PD1L2; PDCD1 ligand 2; Pdcd1lg2; Pdl2; Programmed cell death 1 ligand 2; Programmed death ligand 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800282779817,"sku":"49189S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-49189s","provider":"Iright","version":"1.0","type":"link"}