{"product_id":"cst-4939s","title":"CST,  4939S, Axl (C2B12) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Axl. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Axl (C2B12) Rabbit Monoclonal Antibody (CST #4939) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAxl (C2B12) Rabbit Monoclonal Antibody detects endogenous levels of Axl protein.\nSpecies Reactivity: Human, Monkey, Pig\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant human Axl proteins.\n\u003cb\u003eBackground\u003c\/b\u003e\nAxl, Sky, and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB (2,3). A large body of evidence supports a role for Gas6\/Axl signaling in cell growth and survival in normal and cancer cells (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nARK; AXL; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming sequence\/gene; JTK11; oncogene AXL; Tyro7; Tyrosine-protein kinase receptor UFO; UFO\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk Pg\nSENSITIVITY: Endogenous\nMW (kDa): 138\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799699181737,"sku":"4939S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-4939s","provider":"Iright","version":"1.0","type":"link"}