{"product_id":"cst-49662sf","title":"CST,  49662SF, PNPLA3 (E7N6O) Rabbit Monoclonal Antibody (BSA and Azide Free)","description":"Monoclonal Antibody for studying PNPLA3 mouse. Validated for Western Blotting,Immunohistochemistry (Paraffin). Highly specific and rigorously validated in-house, PNPLA3 (E7N6O) Rabbit Monoclonal Antibody (BSA and Azide Free) (CST #49662) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nThis product is the carrier free version of product #95546. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol. This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT\u0026amp;RUN or CUT\u0026amp;Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us . Optimal dilutions\/concentrations should be determined by the end user. BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.\n\u003cb\u003eFormulation\u003c\/b\u003e\nSupplied in 1X PBS (10 mM Na 2 HPO 4 , 3 mM KCl, 2 mM KH 2 PO 4 , and 140 mM NaCl (pH 7.8)). BSA and Azide Free. For standard formulation of this product see product # 95546 .\n\u003cb\u003eStorage\u003c\/b\u003e\nStore at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze\/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPNPLA3 (E7N6O) Rabbit Monoclonal Antibody (BSA and Azide Free) recognizes transfected levels of total PNPLA3 protein by western blot and endogenous levels of total PNPLA3 protein by immunohistochemistry.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val184 of murine PNPLA3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPNPLA3, also known as adiponutrin, is a protein encoded by the gene. It is a member of the patatin-like phospholipase domain (PNPLA) family of proteins, which are involved in various lipid metabolic processes. PNPLA3 is expressed primarily in the liver and adipose tissue, where it is localized to lipid droplets (1). PNPLA3 is also associated with several diseases, including nonalcoholic fatty liver disease (NAFLD). NAFLD is a spectrum of liver diseases that can range from simple steatosis (fatty liver) to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC) (2). PNPLA3 is the strongest genetic risk factor for NAFLD and its associated complications (3). Mouse PNPLA3 is a valuable tool for studying the role of PNPLA3 in human health and disease (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n1-acylglycerol-3-phosphate O-acyltransferase Pnpla3; Acylglycerol O-acyltransferase; Acylglycerol transacylase; Adiponutrin; Adpn; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon; Lysophosphatidic acid acyltransferase; patatin-like phospholipase domain containing 3; Patatin-like phospholipase domain-containing protein 3; PLPL3; Pnpla3\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous (IHC-P), Transfected (W)\nMW (kDa): 58\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800100720809,"sku":"49662SF","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-49662sf","provider":"Iright","version":"1.0","type":"link"}