{"product_id":"cst-49671t","title":"CST,  49671T, TAP1 (E4T4F) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TAP1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TAP1 (E4T4F) Rabbit Monoclonal Antibody (CST #49671) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTAP1 (E4T4F) Rabbit Monoclonal Antibody recognizes endogenous levels of total TAP1 protein. This antibody does not cross-react with TAP2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human TAP1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCD8 cytotoxic T cells recognize peptides presented by MHC class I molecules on the surface of infected cells and tumor cells. The transporters associated with antigen processing 1 and 2 (TAP1 and TAP2) form the TAP complex, which resides on the ER membrane and transports peptides from the cytoplasm into the ER for loading onto MHC class I molecules (1-8). In addition, TAP localized to endosomal membranes is important for cross-presentation by dendritic cells (9,10). IFN-γ produced by T cells and NK cells in response to infection causes upregulation of TAP1 and TAP2, resulting in increased antigen presentation to T cells (11). Some viral proteins inhibit TAP function or downregulate TAP expression, resulting in viral immune evasion (12,13). In addition, investigators have observed reduced TAP expression in a variety of tumor types, and it is thought to be one mechanism for tumor immune evasion (14).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nABC transporter, MHC 1; ABC17; ABCB2; Antigen peptide transporter 1; APT1; ATP-binding cassette sub-family B member 2; ATP-binding cassette, sub-family B (MDR\/TAP), member 2; D6S114E; FLJ26666; FLJ41500; Peptide supply factor 1; Peptide transporter involved in antigen processing 1; Peptide transporter PSF1; Peptide transporter TAP1; PSF-1; PSF1; Really interesting new gene 4 protein; RING4; TAP1; TAP1N; transporter 1 ATP-binding cassette sub-family B; transporter 1, ATP binding cassette subfamily B member; transporter 1, ATP-binding cassette, sub-family B; transporter 1, ATP-binding cassette, sub-family B (MDR\/TAP); transporter associated with antigen processing; transporter, ATP-binding cassette, major histocompatibility complex, 1; Y3\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 68\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799720939689,"sku":"49671T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-49671t","provider":"Iright","version":"1.0","type":"link"}