{"product_id":"cst-4989s","title":"CST,  4989S, Catenin delta-1 Antibody","description":"Polyclonal Antibody for studying Catenin-delta. Validated for Western Blotting. Highly specific and rigorously validated in-house, Catenin delta-1 Antibody (CST #4989) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCatenin delta-1 Antibody detects endogenous levels of total catenin δ-1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human catenin δ-1. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nCatenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function (1). Catenin δ-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin δ-1, which modulates RhoA, Rac, and cdc42 proteins (1). Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBCDS2; Cadherin-associated Src substrate; CAS; catenin (cadherin-associated protein), delta 1; catenin delta 1; Catenin delta-1; CTND1; CTNND; CTNND1; KIAA0384; p120; p120 catenin; p120(cas); p120(ctn); P120CAS; P120CTN\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 100\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799736438953,"sku":"4989S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-4989s","provider":"Iright","version":"1.0","type":"link"}