{"product_id":"cst-50047s","title":"CST,  50047S, NUP210 (E9A5G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying NUP210. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, NUP210 (E9A5G) Rabbit Monoclonal Antibody (CST #50047) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNUP210 (E9A5G) Rabbit Monoclonal Antibody recognizes endogenous levels of total NUP210 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro290 of human NUP210 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe nuclear pore complex (NPC) is a multi-subunit protein channel that spans the nuclear envelope and is responsible for the nucleocytoplasmic trafficking of RNA, proteins, and ribonucleoproteins (1,2). Nucleoporin 210 kDa (NUP210), also referred to as nuclear pore glycoprotein 210 (gp210), is one of the three integral membrane proteins of the NPC that have been shown to link the complex to the nuclear envelope (3,4). NUP210 is recruited in later stages of the nuclear pore assembly and is expressed in a cell-type specific manner (5). NUP210 expression has been shown to be induced during myogenic and neural differentiation, and its addition to NPCs is needed for activation of essential cell differentiation genes (6). It has also been shown that NUP210 is required for proper muscle structural gene expression at NPCs by acting as a scaffold for the Mef2C transcriptional complex (7). More recently, was identified as a metastasis susceptibility gene for estrogen receptor-positive breast cancer (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ22389; GP210; KIAA0906; Nuclear envelope pore membrane protein POM 210; Nuclear pore membrane glycoprotein 210; Nuclear pore protein gp210; nucleoporin 210; nucleoporin 210kDa; Nucleoporin Nup210; NUP210; PO210; POM210; Pore membrane protein of 210 kDa\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 210\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799744663721,"sku":"50047S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-50047s","provider":"Iright","version":"1.0","type":"link"}