{"product_id":"cst-50546t","title":"CST,  50546T, LRRC15 (E4X8J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying LRRC15. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, LRRC15 (E4X8J) Rabbit Monoclonal Antibody (CST #50546) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 52305 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLRRC15 (E4X8J) Rabbit Monoclonal Antibody recognizes endogenous levels of total LRRC15 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu100 of human LRRC15 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nLRRC15 (Leucine-rich repeat-containing protein 15, LIB) is a transmembrane protein belonging to the LRR family of proteins involved in cell-cell and cell-ECM (extracellular matrix) interactions (1-4). It has been identified as a marker for TGF-β-driven CAFs (cancer-associated fibroblasts), which are associated with immunotherapy resistance (3,4). LRRC15 is highly expressed in multiple solid tumor types, with low expression in normal tissues, making it a good therapeutic candidate for cancers with high stromal content, such as pancreatic cancer, non-small cell lung cancer (NSCLC), and triple-negative breast cancer (3,4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nhLib; leucine rich repeat containing 15; leucine-rich repeat protein induced by beta amyloid; Leucine-rich repeat protein induced by beta-amyloid homolog; Leucine-rich repeat-containing protein 15; LIB; LRC15; LRRC15\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 80-100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799773728937,"sku":"50546T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-50546t","provider":"Iright","version":"1.0","type":"link"}