{"product_id":"cst-50703s","title":"CST,  50703S, RBM4 Antibody","description":"Polyclonal Antibody for studying RBM4. Validated for Western Blotting. Highly specific and rigorously validated in-house, RBM4 Antibody (CST #50703) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nRBM4 Antibody recognizes endogenous levels of total RBM4 protein. This antibody also detects RBM4B protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro317 of human RBM4 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nRBM4 functions as an RNA-binding protein and precursor mRNA splicing factor that antagonizes activity of PTBP1-mediated splicing (1-4). Upon phosphorylation at Ser309, RBM4 accumulates in stress granules and suppresses cap-dependent translation through eIF4A (3). Exon skipping of MEF2C by RBM4 has been shown to play a key role in the differentiation of brown adipocytes (5). The splicing activities of RBM4 seem to suppress tumorigenesis in the context of multiple cancer types (5-8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp547K0918; hLark; LARK; Lark homolog; MGC75138; RBM4; RBM4A; RNA binding motif protein 4; RNA-binding motif protein 4; RNA-binding motif protein 4a; RNA-binding protein 4; transcriptional coactivator CoAZ; ZCCHC21; ZCRB3A; zinc finger CCHC-type and RNA binding motif 3A\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 41\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799779692713,"sku":"50703S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-50703s","provider":"Iright","version":"1.0","type":"link"}