{"product_id":"cst-50837s","title":"CST,  50837S, TFB2M (E5P6W) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TFB2M. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TFB2M (E5P6W) Rabbit Monoclonal Antibody (CST #50837) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTFB2M (E5P6W) Rabbit Monoclonal Antibody recognizes endogenous levels of total TFB2M protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu388 of human TFB2M protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTranscription factor A of the mitochondria (TFAM) and transcription factor B2 of the mitochondria (TFB2M) are critical components of the mitochondrial RNA polymerase machinery (1,2). TFB2M binds to POLRMT and induces structural changes, enabling promoter opening (3,4). The ability of TFB2M to bind at mtDNA promoters is regulated by phosphorylation (5). TFB2M has also been shown to have methyltransferase activity towards rRNA (6). TFB2M can be overexpressed in hepatocellular carcinoma, where it promotes growth and metastasis through ROS-Akt-NF-κB signaling (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDimethyladenosine transferase 2, mitochondrial; FLJ22661; FLJ23182; h-mtTFB; h-mtTFB2; HCV NS5A-transactivated protein 5; Hepatitis C virus NS5A-transactivated protein 5; Hkp1; hTFB2M; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; mtTFB2; NS5ATP5; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; TFB2M; transcription factor B2, mitochondrial\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 38\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799780642985,"sku":"50837S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-50837s","provider":"Iright","version":"1.0","type":"link"}