{"product_id":"cst-50844t","title":"CST,  50844T, MEX3C (D5T2Z) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MEX3C. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MEX3C (D5T2Z) Rabbit Monoclonal Antibody (CST #50844) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMEX3C (D5T2Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total MEX3C protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala54 of human MEX3C protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMEX3C is an RNA-binding E3 ubiquitin ligase implicated in a diverse set of biological functions. Along with PIGN and ZNF516, MEX3C has been identified as a suppressor of chromosome instability (CIN), which drives intratumor heterogeneity and has been associated with poor prognosis in colon cancer. Silencing of the gene induces chromosome instability through replication stress\/impaired replication fork progression (1). In mice, absence of the gene causes growth retardation and reduced insulin-like growth factor 1 (IGF1)Â expression (2). Researchers have shown that murine MEX3C plays a role in controlling energy expenditure, physical activity and degree of adiposity (3,4). In the immune system, MEX3C is involved in post-transcriptional regulation of HLA-A2 (5), and plays a role in eliciting antiviral response (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBM-013; FLJ38871; mex-3 homolog C (C. elegans); mex-3 RNA binding family member C; MEX-3C; MEX3C; MEX3C variant 1; MEX3C variant 2; ring finger and KH domain containing 2; RING finger and KH domain-containing protein 2; RING finger protein 194; RING-type E3 ubiquitin transferase MEX3C; RKHD2; RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein MEX3C; RNF194\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 80\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799780774057,"sku":"50844T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-50844t","provider":"Iright","version":"1.0","type":"link"}