{"product_id":"cst-51142s","title":"CST,  51142S, Angiomotin (E3E7X) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying AMOT. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Angiomotin (E3E7X) Rabbit Monoclonal Antibody (CST #51142) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAngiomotin (E3E7X) Rabbit Monoclonal Antibody recognizes endogenous levels of angiomotin isoform 1 (full-length) protein. This antibody does not recognize the amino-terminally truncated angiomotin isoform 2 protein. This antibody cross-reacts with the angiomotin family members, angiomotin-like 1 (AMOTL1) and angiomotin-like 2 (AMOTL2).\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human angiomotin protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nAngiomotin (AMOT) is a widely expressed cell junction protein initially identified through its ability to bind angiostatin. Alternative splicing results in two isoforms of angiomotin, the full-length p130 and the amino-terminally truncated p80. These isoforms, along with angiomotin-like 1 (AMOTL1) and angiomotin-like 2 (AMOTL2), comprise the Motin protein family. Angiomotin is important in endothelial cell polarity, migration, and blood vessel formation during development, as well as in signaling through small GTPases and the Hippo\/YAP pathway (reviewed in 1). Research studies have shown that angiomotin expression regulates migration and proliferation of breast cancer cells (2,3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAMOT; Angiomotin; angiomotin p130 isoform; angiomotin p80 isoform; KIAA1071\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 140, 130, 100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799782740137,"sku":"51142S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-51142s","provider":"Iright","version":"1.0","type":"link"}