{"product_id":"cst-5122s","title":"CST,  5122S, FAM129B Antibody","description":"Polyclonal Antibody for studying FAM129B. Validated for WB,IP,IF,F. Highly specific and rigorously validated in-house, FAM129B Antibody (CST #5122) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nImmunofluorescence (Immunocytochemistry): 1:50\nFlow Cytometry (Fixed\/Permeabilized): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry), Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nFAM129B Antibody recognizes endogenous levels of total FAM129B protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu705 of human Fam129B protein. Antibodies were purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nFAM129B\/Niban-like protein 1 (family with sequence similarity 129, member B) belongs to a poorly characterized family of Niban proteins that also includes FAM129A\/Niban and FAM129C\/Niban-like protein 2. FAM129A\/Niban is implicated in the ER stress response and is upregulated at the protein level in thyroid carcinoma (1,2). FAM129C\/Niban-like protein 2 is preferentially expressed in B-cells and is one of five biomarkers upregulated in whole blood from patients with colorectal carcinoma (3,4). FAM129B is broadly expressed and has been shown to be a downstream target of B-Raf in melanoma cells (5). Though FAM129B does not appear to regulate cell growth and division, phosphorylation of FAM129B by B-Raf is essential for the invasive potential of melanoma and non-melanoma cell lines (5). Deletion of FAM129B in melanoma cells significantly impairs B-Raf\/MEK\/Erk-dependent invasion into the extracellular matrix (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nbA356B19.6; C9orf88; DKFZP434H0820; FAM129B; family with sequence similarity 129 member B; family with sequence similarity 129, member B; FLJ13518; FLJ22151; FLJ22298; Meg-3; Melanoma invasion by ERK; MINERVA; NIBA2; niban apoptosis regulator 2; Niban-like protein 1; NIBAN2; NIBL1; OC58; Protein FAM129B; Protein Niban 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 95\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799783198889,"sku":"5122S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-5122s","provider":"Iright","version":"1.0","type":"link"}