{"product_id":"cst-51434s","title":"CST,  51434S, Echinomycin","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nEchinomycin is supplied as a lyophilized powder. For a 1 mM stock, reconstitute 1 mg of powder in 0.91 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles .\n\u003cb\u003eBackground\u003c\/b\u003e\nThe small-molecule Echinomycin is an inhibitor of hypoxia-inducible factor 1 (HIF1), an important transcription factor controlling the expression of genes that facilitate the response to a hypoxic environment. Cellular response to hypoxia involves angiogenesis, erythropoiesis, cell cycle, metabolism, and apoptosis, all of which are important for metastasis and tumor progression. Echinomycin inhibits HIF-1α and HIF-1β binding to a hypoxia-responsive element sequence of promoters of hypoxia-responsive genes (1). Echinomycin eliminated the ability of mouse lymphoma and human acute myeloid leukemia (AML) cancer stem cells to form colonies, and inhibited human AML in a xenogeneic model through preferential elimination of cancer stem cells (2). Inhibition of HIF-1α by Echinomycin can reduce the effects of acute graft-versus-host disease and extend leukemia free survival following allogeneic hematopoietic stem cell transplantation (3). Echinomycin inhibited adipogenesis and suppressed adipocyte differentiation in 3T3-L1 WAT preadipocytes, which may lead to a new therapeutic approach targeting obesity and diabetes (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nNSC-13502; Quinomycin A","brand":"CST","offers":[{"title":"Default Title","offer_id":46800695918761,"sku":"51434S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-51434s","provider":"Iright","version":"1.0","type":"link"}