{"product_id":"cst-51468t","title":"CST,  51468T, TRAT1 (E3L8A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TRAT1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TRAT1 (E3L8A) Rabbit Monoclonal Antibody (CST #51468) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTRAT1 (E3L8A) Rabbit Monoclonal Antibody recognizes endogenous levels of total TRAT1 protein. This antibody detects TRAT1 monomers and homodimers.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TRAT1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nT cell receptor-associated transmembrane adaptor 1 (TRAT1) is a transmembrane adaptor protein, which is expressed as a disulfide-linked homodimer on the surface of cells belonging to the T and NK lineage. Research studies have demonstrated that TRAT1 is associated with the T cell receptor (TCR) signaling complex. Furthermore, T cell activation promotes tyrosine phosphorylation of the TRAT1 cytoplasmic tail, which facilitates the recruitment of SH2 domain-containing signaling proteins known to regulate T cell function (1). TRAT1 may also modulate TCR signaling by stabilizing the surface expression of the TCR signaling complex (2).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nHSPC062; pp29\/30; T cell receptor associated transmembrane adaptor 1; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell receptor-associated transmembrane adapter 1; T-cell receptor-interacting molecule; TCRIM; TRAT1; TRIM\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 28, 60\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799784575145,"sku":"51468T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-51468t","provider":"Iright","version":"1.0","type":"link"}