{"product_id":"cst-51623s","title":"CST,  51623S, Phospho-Syntenin-1\/MDA9 (Ser60) (F4T2K) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying syntenin (Ser60) phosphate. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-Syntenin-1\/MDA9 (Ser60) (F4T2K) Rabbit Monoclonal Antibody (CST #51623) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPhospho-Syntenin-1\/MDA9 (Ser60) (F4T2K) Rabbit Monoclonal Antibody recognizes transfected levels of syntenin-1\/MDA9 protein only when phosphorylated at Ser60.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser60 of human syntenin-1\/MDA9 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSyntenin-1, also known as MDA9 or SDCBP, is a member of the PDZ family of proteins (1), defined by the presence of a PDZ protein interaction domain. Syntenin-1, via its PDZ domain, functions as a scaffold adaptor protein that regulates numerous signal transduction pathways, including FAK, Src, TGF-βR1, EGFR, and IGF1R (2-5). Aberrantly elevated expression of syntenin-1 has been found in various cancers and has been linked to the growth and invasion of tumor cells (5-7). In the central nervous system, syntenin-1 has been shown to mediate neuron dendrite protrusion and spine formation through its interaction with syndecan and Rheb (8). Syntenin-1 is also a key component of the syndecan\/syntenin\/ALIX pathway, and it has been shown to contribute directly to the formation and internalization of exosomes (9-11). Syntenin-1\/MDA9 has been shown to be phosphorylated at Ser61 by ULK1 in mouse, which is highly conserved with Ser60 in human (12).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nMDA-9; MDA9; melanoma differentiation associated protein-9; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; SDCB1; SDCBP; ST1; SYCL; syndecan binding protein; syndecan binding protein (syntenin); Syndecan-binding protein 1; syntenin; Syntenin-1; TACIP18\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Transfected Only\nMW (kDa): 30\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799786082473,"sku":"51623S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-51623s","provider":"Iright","version":"1.0","type":"link"}