{"product_id":"cst-51755s","title":"CST,  51755S, ANT1\/SLC25A4 (E3E9Y) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SLC25A4\/ANT1. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, ANT1\/SLC25A4 (E3E9Y) Rabbit Monoclonal Antibody (CST #51755) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nImmunofluorescence (Immunocytochemistry): 1:200 - 1:800\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nANT1\/SLC25A4 (E3E9Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total ANT1\/SLC25A4 protein. This antibody does not cross-react with ANT2\/SLC25A5 protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala150 of human ANT1\/SLC25A4 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nAdenine nucleotide translocators (ANTs) are a family of mitochondrial proteins that exchange ATP and ADP across the mitochondrial inner membrane. ANT1, also known as solute carrier family 25 member 4 (SLC25A4), is the isoform predominantly expressed in heart, muscle, and brain (1,2). Homozygous loss-of-function mutations in causes cardiomyopathy (2,3). In addition, ANT1\/SLC25A4 is shown to be required for mitophagy (3). Furthermore, research studies show that ANT1\/SLC25A4 facilitates mitochondrial permeability transition induced by bile acids and, therefore, pyroptosis (4). ANT1\/SLC25A4 may mediate the release of ATP from mitochondria to the cytoplasm in this process, which is critical for pyroptosome assembly (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAAC1; Adenine nucleotide translocator 1; adenine nucleotide translocator 1 (skeletal muscle); adenine nucleotide translocator), member 4; ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart\/skeletal muscle; ADP,ATP carrier protein, heart\/skeletal muscle isoform T1; ADP\/ATP translocase 1; ADT1; ANT; ANT 1; ANT1; heart\/skeletal muscle ATP\/ADP translocator; MTDPS12; MTDPS12A; PEO2; PEO3; PEOA2; SLC25A4; solute carrier family 25 (mitochondrial carrier; Solute carrier family 25 member 4; T1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 28\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799787819177,"sku":"51755S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-51755s","provider":"Iright","version":"1.0","type":"link"}