{"product_id":"cst-51888t","title":"CST,  51888T, GRAP (F9U7T) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying GRAP. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, GRAP (F9U7T) Rabbit Monoclonal Antibody (CST #51888) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nGRAP (F9U7T) Rabbit Monoclonal Antibody recognizes endogenous levels of total GRAP protein. This antibody does not cross-react with GRB2 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human GRAP protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nGRB2-related adaptor protein (GRAP) is a member of the GRB2 family of signaling adaptor proteins, and its expression is largely restricted to lymphoid tissues (1,2). Similar to the structure of other members of the GRB2 family of adaptor proteins, GRAP contains a central SH2 domain flanked on either side by SH3 domains that allow for it to directly associate with other signaling molecules (1). Research studies have suggested that, unlike GRB2, GRAP may hinder T cell effector functions by disrupting Ras\/MAPK signaling downstream of the T cell receptor signaling complex (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDFNB114; GRAP; GRB2 related adaptor protein; GRB2-related adapter protein; GRB2-related adaptor protein; growth factor receptor-bound protein 2-related adaptor protein; MGC64880; Q13588\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 25\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799788507305,"sku":"51888T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-51888t","provider":"Iright","version":"1.0","type":"link"}