{"product_id":"cst-52184s","title":"CST,  52184S, NKY-80","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nNKY-80 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 1 mg of powder in 0.44 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles .\n\u003cb\u003eBackground\u003c\/b\u003e\nNKY-80 is an inhibitor of adenylyl cyclase (AC) catalytic activity, an essential enzyme that generates cyclic adenosine 3'5'-monophosphate (cAMP) from ATP. At least six distinct classes of ACs have been identified, with isozymes differing in cell localization, tissue distribution, and signaling pathways. NKY-80 is capable of blocking several different AC isozymes, inhibiting type V more strongly (IC = 8.3 μM) than type II (IC = 1.7 mM) or type III (IC = 132 μM). NKY-80 also potently inhibits AC type VI, with an affinity close to that of AC type V (1,2). In a rat model of Parkinson's disease, NKY-80 blocked increases of both [(3)H]-GABA release and cAMP production, indicating that AC V\/VI expression is a major determinant of increased GABAergic transmission in rats with L-DOPA induced severe dyskinesia (3). In a study of immune response in insects, NKY-80 reduced levels of hemocyte mobilization in response to bacterial challenge, indicating a role for AC and cAMP in hemocyte regulation and the immune response (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone","brand":"CST","offers":[{"title":"Default Title","offer_id":46800695984297,"sku":"52184S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-52184s","provider":"Iright","version":"1.0","type":"link"}