{"product_id":"cst-52445s","title":"CST,  52445S, HGF beta (D6S7D) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying HGF beta subunit. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, HGF beta (D6S7D) Rabbit Monoclonal Antibody (CST #52445) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 57408 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nHGF beta (D6S7D) Rabbit Monoclonal Antibody recognizes endogenous levels of total HGF protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human HGF protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe Hepatocyte Growth Factor (HGF, also known as Scatter Factor) was initially discovered as a mitogenic cytokine that induced hepatocyte replication and proliferation (1-3). HGF is produced by stromal cells where it is processed by extracellular serine proteases into a heterodimer consisting of alpha and beta subunits (4). Through activation of its receptor, cMET, HGF has a wide range of effects beyond hepatocytes that includes angiogenesis, epithelial cell proliferation and morphogenesis, and tissue protection and regeneration (5). The HGF-cMET axis has been associated with several diseases, including cancer, where HGF has been shown to promote invasion, metastasis, and drug resistance (6,7). These research studies suggest that HGF is a potential diagnostic and therapeutic target.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDFNB39; F-TCF; fibroblast-derived tumor cytotoxic factor; Hepatocyte growth factor; hepatocyte growth factor (hepapoietin A; Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain; Hepatopoeitin-A; Hepatopoietin-A; HGF; HGFB; HPTA; lung fibroblast-derived mitogen; Scatter factor; scatter factor); SF\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 35, 85\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799790964905,"sku":"52445S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-52445s","provider":"Iright","version":"1.0","type":"link"}