{"product_id":"cst-52671s","title":"CST,  52671S, PVRIG Antibody","description":"Polyclonal Antibody for studying PVRIG. Validated for Western Blotting. Highly specific and rigorously validated in-house, PVRIG Antibody (CST #52671) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPVRIG Antibody recognizes endogenous levels of total PVRIG protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala318 of human PVRIG protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nPoliovirus Receptor-Related Immunoglobulin Domain-Containing Protein (PVRIG; also known as CD112 receptor) is a multiple transmembrane protein expressed on the surface of T cells and NK cells, predominantly on memory and effector CD8 T cells. PVRIG expression is upregulated after T cell activation with anti-CD3 and anti-CD28 antibodies. PVRIG competes with DNAM-1\/CD226 for interaction with the receptor ligand Nectin-2. Upon ligation of PVRIG and Nectin-2, T cell proliferation is inhibited, suggesting PVRIG is a co-inhibitory receptor that dampens T cell functions (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC7orf15; CD112 receptor; CD112R; MGC104322; MGC138295; MGC138297; MGC2463; nectin-2 receptor; poliovirus receptor related immunoglobulin domain containing; Poliovirus receptor-related immunoglobulin domain-containing protein; PVR related immunoglobulin domain containing; PVRIG; Transmembrane protein PVRIG\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 30-40\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799793356969,"sku":"52671S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-52671s","provider":"Iright","version":"1.0","type":"link"}