{"product_id":"cst-53537s","title":"CST,  53537S, Captopril","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nCaptopril is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 5 mg of powder in 1.15 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nCaptopril is a selective and reversible angiotensin-converting enzyme (ACE) inhibitor with an IC value of 0.022 μM (1). This small molecule selectively lowers angiotensin II, a hormone that when upregulated has been linked to increased hypertension, atherosclerosis, myocardial hypertrophy, and obesity (2-5). Captopril has also been shown to regulate inflammatory pathways as a reversible inhibitor of leukotriene A4 (LTA4) hydrolase, reducing leukotriene B4 synthesis (6).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800696049833,"sku":"53537S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-53537s","provider":"Iright","version":"1.0","type":"link"}