{"product_id":"cst-53626s","title":"CST,  53626S, MAP7 (E8K7O) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MAP7. Validated for Western Blotting,Immunofluorescence (Frozen),Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, MAP7 (E8K7O) Rabbit Monoclonal Antibody (CST #53626) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunofluorescence (Frozen): 1:800 - 1:3200\nImmunofluorescence (Immunocytochemistry): 1:200 - 1:800\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunofluorescence (Frozen), Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMAP7 (E8K7O) Rabbit Monoclonal Antibody recognizes endogenous levels of total MAP7 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MAP7 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMAP7 is a member of the Microtubule-Associated Proteins (MAPs) that regulates the stability and function of the cytoskeleton in cells (1). MAP7 facilitates the transport of organelles, such as mitochondria and lysosomes, via recruitment of kinesin-1 (2). This role of MAP7 in organelle transport occurs in neuronal and non-neuronal cells, including oocytes, and in S2 cells and mammalian muscle cells (4,5). In addition to promoting organelle transport via kinesin-1 recruitment, MAP7 also contributes to the morphogenesis of axons that is domain-specific, whereas the full-length MAP7 promotes branch maturation, N- and P- domains are responsible for branch formation, and the C-terminal kinesin-interacting domain contributes to the axonal growth (3,6). MAP7 and the paralog MAP7D1 directly interact with disheveled, an effector of the Wnt5a β-catenin-independent pathway, regulating the microtubule remodeling, cell migration, and cell adhesion in HeLa cells (7). MAP7 is considered a biomarker in a model to treat multiple sclerosis based on the tolerogenic dendritic cells induced by vitamin D3 (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\ndJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115)); E-MAP-115; EMAP115; Ensconsin; Epithelial microtubule-associated protein of 115 kDa; MAP-7; MAP7; microtubule associated protein 7; Microtubule-associated protein 7\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 110\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799802007721,"sku":"53626S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-53626s","provider":"Iright","version":"1.0","type":"link"}