{"product_id":"cst-53771t","title":"CST,  53771T, ICA1L (F6I4E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ICA1L. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, ICA1L (F6I4E) Rabbit Monoclonal Antibody (CST #53771) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nICA1L (F6I4E) Rabbit Monoclonal Antibody recognizes endogenous levels of total ICA1L protein. A band of unknown origin at 21 kDa is detected by western blot.\nSpecies Reactivity: Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val134 of human ICA1L protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nIslet cell autoantigen 1-like protein (ICA1L) expression is enriched in glutamatergic excitatory neurons (1). ICA1L plays a crucial role in myelination, where it has recently been linked to multiple sclerosis (MS) pathogenesis (2,3). is a newly discovered risk gene for MS but has previously been identified as a risk gene for cerebrovascular disease by several genome-wide association studies (GWAS). Recent proteome-wide association studies (PWAS) found that diseases associated with also include cerebrovascular disease (4-7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nALS2CR14; ALS2CR15; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 14; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 15; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein; DKFZp434E1919; ICA1L; Ica69-related protein; islet cell autoantigen 1 like; Islet cell autoantigen 1-like protein; islet cell autoantigen 1,69kDa-like; MGC138440\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M R\nSENSITIVITY: Endogenous\nMW (kDa): 55\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800102588585,"sku":"53771T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-53771t","provider":"Iright","version":"1.0","type":"link"}