{"product_id":"cst-53943s","title":"CST,  53943S, Human FGF-4 Recombinant Protein","description":"Growth Factors and Cytokines for studying FGF4 in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nHuman FGF-4 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant human FGF-4 was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nFGF-4 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-4 functions as a signaling molecule that is involved in many important processes (1,2). FGF-4 binds to FGFR1 and is required for cardiac gene expression, particularly during second heart field (SHF) proliferation and chamber formation in cooperation with the Sonic hedgehog gene ( ) during heart development (3,4). FGF-4 knockout mice showed developmental defects in embryos thus suggesting that FGF-4 facilitates survival and growth of the inner cell mass during the postimplantation phase of development (1). Since FGFs are involved in gastrointestinal development, upregulation of FGF-4 in pluripotent stem cells has been used to direct their differentiation for the generation of intestinal organoids (5).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800714858665,"sku":"53943S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-53943s","provider":"Iright","version":"1.0","type":"link"}